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Bevacizumab as a monoclonal antibody inhibits mitochondrial complex II in isolated rat heart mitochondria: ameliorative effect of ellagic acid.
Mohammad Khanlou E, Atashbar S, Kahrizi F, Shokouhi Sabet N, Salimi A. Mohammad Khanlou E, et al. Drug Chem Toxicol. 2022 Jan;45(1):456-463. doi: 10.1080/01480545.2020.1715423. Epub 2020 Jan 23. Drug Chem Toxicol. 2022. PMID: 31973585
The inhibition of complex II is paralleled by the decreased MMP, mitochondrial swelling, and ROS formation. Also, we showed that EA (10-100 M) as an antioxidant and natural agent significantly decreases mitochondrial toxicity induced by BEV. ...
The inhibition of complex II is paralleled by the decreased MMP, mitochondrial swelling, and ROS formation. Also, we showed that EA (10-100 …
Stabilization of Mitochondrial Function by Ellagic Acid Prevents Celecoxib-induced Toxicity in Rat Cardiomyocytes and Isolated Mitochondria.
Atashbar S, Sabzalipour T, Salimi A. Atashbar S, et al. Drug Res (Stuttg). 2021 Apr;71(4):219-227. doi: 10.1055/a-1308-1585. Epub 2020 Dec 4. Drug Res (Stuttg). 2021. PMID: 33276407
In order to do this, isolated cardiomyocytes and mitochondria were pretreated with 3 different concentrations of EA (10, 50 and 100 M), after which celecoxib (16 g/ml) was added to promote deleterious effects on cells and mitochondria. ...Also, our results revealed that co …
In order to do this, isolated cardiomyocytes and mitochondria were pretreated with 3 different concentrations of EA (10, 50 and 100 M …
Calcitriol Reduces Adverse Effects of Diclofenac on Mitochondrial Function in Isolated Rat Heart Mitochondria.
Khezri S, Atashbar S, Azizian S, Shaikhgermchi Z, Kurdpour P, Salimi A. Khezri S, et al. Drug Res (Stuttg). 2020 Jul;70(7):317-324. doi: 10.1055/a-1167-0691. Epub 2020 May 15. Drug Res (Stuttg). 2020. PMID: 32413916
Then isolated mitochondria were pretreated with 3 different concentrations of calcitriol (2.5, 5 and 10 M) for 5 min at 37C, after which DIC (10 g/ml) was added to promote deleterious effects on mitochondria. ...Also, our results revealed that co-administration of calcitri …
Then isolated mitochondria were pretreated with 3 different concentrations of calcitriol (2.5, 5 and 10 M) for 5 min at 37C, after wh …
Gallic acid inhibits celecoxib-induced mitochondrial permeability transition and reduces its toxicity in isolated cardiomyocytes and mitochondria.
Salimi A, Atashbar S, Shabani M. Salimi A, et al. Hum Exp Toxicol. 2021 Dec;40(12_suppl):S530-S539. doi: 10.1177/09603271211053299. Epub 2021 Oct 29. Hum Exp Toxicol. 2021. PMID: 34715756
RESEARCH DESIGN: The isolated cardiomyocytes and mitochondria were divided into various group, namely, control, celecoxib, celecoxib + GA (10, 50, and 100 M). Several cellular and mitochondrial parameters such as cell viability, lipid peroxidation, succinate dehydrogenase …
RESEARCH DESIGN: The isolated cardiomyocytes and mitochondria were divided into various group, namely, control, celecoxib, celecoxib + GA (1 …